Brendel was replaced by Matt Hennessy in the middle of Sunday’s game, and the offensive line didn’t seem to miss a beat, so Hennessy will probably take over as the starter going forward.
For Huff, San Francisco will need to find someone else to rely on. They’re already missing Nick Bosa, who is out for the year with a torn ACL, and Yetur Gross-Matos, who was out in Week 7 with an injury. Sam Okuayinonu, Mykel Williams and Trevis Gipson are really the only edge rushers left on the active roster.
The 49ers may have to consider bringing Robert Beal or Williams Bradley-King up from the practice squad, or they could sign a free agent.
49ers cornerback Renardo Green is also considered day-to-day with a toe injury that he suffered on Sunday. However, Shanahan clarified he’s not dealing with turf toe.
Kyle Shanahan is known for his calm. For his ability to turn chaos into order, to find solutions in moments when others crumble. But on Monday, that trademark calm cracked. Standing before the cameras, his jaw tightened slightly as he delivered three sentences that reshaped the 49ers’ season: “Fred’s going to miss time. Trent’s still being evaluated. Deebo’s shoulder doesn’t look good.”
It wasn’t just news — it was a gut punch.
For Shanahan, these moments have become a cruel pattern. The 49ers, among the league’s most talented teams, have been repeatedly betrayed by the one opponent they can’t outcoach: injury. Since 2019, San Francisco has led the NFL in games lost by starters to injury. “It’s frustrating,” he admitted later. “You put everything into building continuity, then one play changes everything.”
In the hours after the game, staff trainers and medical personnel worked late into the night. By dawn, the report on Shanahan’s desk told a story of strain and setbacks. Warner’s ankle was swollen, Williams’ MRI revealed inflammation, and Samuel’s x-rays hinted at more damage than expected. When the coach arrived at the facility, his message to the team was short and emotional: next man up doesn’t mean forget who we lost.
Inside the locker room, players described an almost eerie quiet. No loud music, no banter — just focused preparation. Christian McCaffrey was among the first to speak up: “This is the league. Nobody’s going to feel sorry for us. We fight.” His tone captured the spirit Shanahan has cultivated — accountability without excuses.
The broader NFL community reacted with empathy. Analysts on ESPN described the 49ers as “one of the most cursed teams when it comes to durability.” Former quarterback Alex Smith called it “a test of leadership that defines careers.” On social media, rival fans offered rare sympathy, noting how injuries robbed last season’s NFC Championship of its full potential.
Yet, even as the news spread, Shanahan began strategizing. Backup plans were discussed: Oren Burks filling in at linebacker, Jaylon Moore stepping up on the left side, rookie Ronnie Bell potentially earning a larger offensive role. “You can’t replace superstars,” Shanahan said. “But you can prepare like you expect to.”
Those who know him best say adversity sharpens him. In 2020, he managed to keep a battered roster competitive despite losing both starting quarterbacks. This, however, feels different — more personal. Warner, Williams, and Samuel aren’t just names on a roster; they’re pillars of his system, men who’ve been with him through heartbreak and triumph.
As the day ended, Shanahan walked through the empty practice field, talking quietly with defensive coordinator Steve Wilks. “We’ll get through it,” he said, half to himself. The lights dimmed behind them, and for a moment, the head coach who’s seen it all seemed very human — not a strategist, not a play-caller, but a man who refuses to let bad luck break his belief.
