John Stamos will be there for Lori Loughlin through thick and thin.

The actor, 62, did not hold back when discussing his former costar’s soon-to-be ex-husband Mossimo Giannulli during an appearance on the the Good Guys podcast Monday, Oct. 20. Reflecting on his longtime friendship with Loughlin, 61 — who played Aunt Becky, the lover of his Uncle Jesse, on Full House in the ‘80s and ‘90s — Stamos praised her for being “a saint.”

“I’m just heartbroken for her right now,” he admitted of her recent split from the clothing designer after 28 years of marriage. “She’s just devastated. For a girl who has lived her life really well, a good person, a good mother, a good wife — I know all this for a fact — to be thrown into now this separation and, you know, exploding, blowing up her family this way,” Stamos said. “I just hate to see her go through this. I really do.”

Stamos noted that he has “really tried to be there for her during this time, and also with the college scandal,” referring to Loughlin and Giannulli pleading guilty in 2020 after they paid $500,000 to get their two daughters, Olivia Jade, 26, and Isabella, 27, into the University of Southern California as fake crew recruits.

Shortly after a press conference of the federal investigation came out, Stamos said he texted the When Hope Calls actress, who was unaware that it was airing on “every channel.” That was the last time he “heard from her for a while.”

In May 2020, Loughlin and Giannulli pleaded guilty to wire and mail fraud. Loughlin was eventually sentenced to two months in federal prison, which she completed in December 2020, and Giannulli received a five-month sentence.

Stamos explained that he has been there to support his longtime friend through it all, and he hasn’t held back his opinions on the role Giannulli has played in the challenges Loughlin has experienced.

“I said, ‘Look, all the negativity or hard hardships that you’ve been through in your life is connected to this guy,’ ” Stamos admitted telling Loughlin of Giannulli. “Whatever he did to her, it busted her up to the core. She put up with a lot over the years of this guy. And again, I’m not going to get into the relationship. It’s not my business. I mean, I know a lot, and I was by her side through a lot of it. She is an angel, and she always made things better. She cleaned everything up. He’s a very successful dude.”

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As for his own relationship with Giannulli, Stamos declared, “I will never talk to him again.”

“He’s a terrible narcissist, and I don’t think you ever get out of that unless you’re able to,” he continued, adding that although he knows a little about Giannulli, he still questions, “How do you bust that up?”

“I pray for this guy,” Stamos concluded. “I pray that he gets a hold of whatever hole that he’s trying to fill, however he’s trying to fill it. I pray that he realizes that what he had was everything that anyone could ever hope for and that he gets some help. I think this guy needs help.”