An NFC West showdown between the Los Angeles Rams (3-1) and San Francisco 49ers (3-1) is on the calendar for Thursday, October 2, 2025 at SoFi Stadium.

How to watch San Francisco 49ers at Los Angeles Rams

• Venue: SoFi Stadium
• Time: 8:15 p.m. ET
• Streaming (in-market viewers): Fubo (Stream now)
• TV: Amazon Prime Video
• Watching in person? Get tickets on StubHub.

San Francisco vs. Los Angeles odds

• Spread: Los Angeles -8.5 (-105), San Francisco +8.5 (-115)
• Favorite Moneyline: Los Angeles -450
• Underdog Moneyline: San Francisco +350
• Total: 45.5
• Total Over Odds: -110
• Total Under Odds: -110

Odds provided by BetMGM.

Injury reports

Rams

TE Tyler Higbee: doubtful (Hip)

S Kamren Kinchens: Full Participation in Practice (Shoulder)

TE Colby Parkinson: Full Participation in Practice (Shoulder)

OL Rob Havenstein: doubtful (Ankle)

49ers

LB Dee Winters: Full Participation in Practice (Knee)

DL Mykel Williams: Full Participation in Practice (Wrist)

DT CJ West: questionable (Thumb)

WR Jordan Watkins: out (Calf)

QB Brock Purdy: out (Toe)

WR Ricky Pearsall: out (Knee)

OL Colton McKivitz: Full Participation in Practice (Calf)

QB Mac Jones: Full Participation in Practice (Knee)

WR Jauan Jennings: out (Ankle)

DL Yetur Gross-Matos: Full Participation in Practice (Knee)

CB Renardo Green: Full Participation in Practice (Neck)

DL Robert Beal: out (Ankle)

Stats to know

• The Rams have averaged 6.2 more points scored this season (25.0) than the 49ers have allowed (18.8).
• Los Angeles’ offense has averaged 388.3 yards per game this season, 107.8 more than the 280.5 San Francisco’s defense has allowed. Los Angeles earns 6.3 yards per play, while San Francisco allows 4.7.
• The 49ers’ average points scored this season (20.0) and the Rams’ average points allowed (20.3) are within 0.3 points.
• Los Angeles has allowed 284.5 yards per game, 83.5 yards fewer than San Francisco has generated (368.0). San Francisco picks up 5.7 yards per play, while Los Angeles allows 5.2.

This watch guide was created using technology provided by Data Skrive.

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Photo: Perry Knotts, Chris Unger / Getty Images