The Indianapolis Colts (3-1) return to Lucas Oil Stadium for NFL Week 5 action against the Las Vegas Raiders (1-3). The Colts are coming off their first loss of the season, 27-20 to the Los Angeles Rams. The Raiders have struggled since winning their opener, falling 25-24 to the Chicago Bears in Week 4 as their last-second field goal try was blocked.
Here are the keys to the Week 5 matchup.
Colts vs. Raiders: Keys to the Week 5 matchup
- Despite losing their third straight game, the Raiders made notable improvements in Week 4. They kept quarterback Geno Smith clean after allowing 12 sacks over the first three games. Las Vegas rushed for 240 yards after failing to reach 100 in any of the first three games.
- Red zone possessions should be interesting: Las Vegas is No. 21 in scoring touchdowns when reaching the opponent’s 20-yard line (50%), while the Colts are the worst defensively (allowing TDs 88.9% of the time). Indy’s offense has sputtered in the red zone (47.5%, No. 25) while Las Vegas’ defense has been stout (39.5%, No. 4).
- The Colts continue to hum offensively: No. 5 in scoring (30.8 points per game), No. 3 in yards (397.3), No. 4 in completion percentage (71.9) and No. 4 in protecting quarterback Daniel Jones (sacks on 3.2% of dropbacks).
Raiders vs. Colts matchups to watch
Ashton Jeanty vs. Colts linebackers
The rookie running back had a breakout in Week 4, rushing for 138 yards, including a 64-yard touchdown, earning the weekly honor as the NFL’s top running back. He has increased his rushing total with each game and has 282 yards with 2 touchdowns. The Colts will try to squelch his upward trend.
Geno Smith vs. Colts defensive backs
The veteran quarterback leads the NFL with 7 interceptions, throwing 3 in Week 4. (He also has 948 passing yards and 6 TDs.) Raiders coach Pete Carroll defended Smith over questions of a possible benching. The Colts allowed 375 passing yards in Week 4 as the Rams took advantage of their battered defensive backfield. Does Smith bounce back?
Maxx Crosby vs. Colts offensive line
The veteran defensive end had a stellar Week 4, with 3 tackles for loss, a forced fumble and his first career interception. If the Colts are missing right guard Matt Goncalves again, Crosby could create headaches. Of course, Crosby has created headaches against fully healthy O-lines.
Las Vegas Raiders injury report vs. Indianapolis Colts for NFL Week 5 on Oct. 5, 2025
Raiders who did not practice Oct. 1: WR Justin Shorter (illness); limited participation: TE Brock Bowers (knee), TE Michael Mayer (concussion), CB Eric Stokes (knee), LB Brennan Jackson (foot); full participation: CB Decamerion Richardson (hamstring).
Start time for Indianapolis Colts-Las Vegas Raiders NFL game start Sunday, Oct. 5, 2025? When is Raiders-Colts NFL football game?
The Indianapolis Colts-Las Vegas Raiders game is at 1 p.m. ET Sunday, Oct. 5, 2025, at Lucas Oil Stadium in Indianapolis.
What channel is Las Vegas Raiders vs Indianapolis Colts game on TV Sunday, Oct. 5, 2025? Where to watch NFL Week 5 football game live
TV: Fox, with Chris Myers (play-by-play), Mark Sanchez (analysis) and Kristina Pink (sideline reporting)
Watch Colts vs. Raiders in Week 5 on Fubo (free trial)
How to stream Colts vs Raiders NFL football game Sunday, Oct. 5, 2025. Where to watch Raiders-Colts Week 5
NFL+, NFL Sunday Ticket and YouTube TV, Fubo
Watch the Colts with a free Fubo trial
Are the Indianapolis Colts favored over the Las Vegas Raiders in NFL Week 5 on Oct. 5, 2025? Indianapolis Colts vs. Las Vegas Raiders betting odds for Oct. 5, 2025
- via BetMGM
- Favorite: Colts by 7 points
- Over/under: 48 total points
- Moneyline: Colts -300, Raiders +240
- ESPN’s matchup predictor gives the Colts a 63.9% chance of winning.
NFL Week 5 schedule
- Thursday, Oct. 2: San Francisco 49ers at Los Angeles Rams, 8:15 p.m., Amazon (summary, box score)
- Sunday, Oct. 5: Minnesota Vikings vs. Cleveland Browns in London, 9:30 p.m., NFL Network (summary, box score)
- Sunday, Oct. 5: Houston Texans at Baltimore Ravens, 1 p.m., CBS (summary, box score)
- Sunday, Oct. 5: Miami Dolphins at Carolina Panthers, 1 p.m., Fox (summary, box score)
- Sunday, Oct. 5: Las Vegas Raiders at Indianapolis Colts, 1 p.m., Fox (summary, box score)
- Sunday, Oct. 5: New York Giants at New Orleans Saints, 1 p.m., CBS (summary, box score)
- Sunday, Oct. 5: Dallas Cowboys at New York Jets, 1 p.m., Fox (summary, box score)
- Sunday, Oct. 5: Denver Broncos at Philadelphia Eagles, 1 p.m., CBS (summary, box score)
- Sunday, Oct. 5: Tennessee Titans at Arizona Cardinals, 4:05 p.m., CBS (summary, box score)
- Sunday, Oct. 5: Tampa Bay Buccaneers at Seattle Seahawks, 4:05 p.m., CBS (summary, box score)
- Sunday, Oct. 5: Detroit Lions at Cincinnati Bengals, 4:25 p.m., Fox (summary, box score)
- Sunday, Oct. 5: Washington Commanders at Los Angeles Chargers, 4:25 p.m., Fox (summary, box score)
- Sunday, Oct. 5: New England Patriots at Buffalo Bills, 8:20 p.m., NBC, Peacock, Telemundo (summary, box score)
- Monday, Oct. 6: Kansas City Chiefs at Jacksonville Jaguars, 8:15 p.m., ABC, ESPN (summary, box score)
- Bye week: Atlanta Falcons, Chicago Bears, Green Bay Packers, Pittsburgh Steelers
Colts 2025 regular-season schedule, results
- Week 1: Indianapolis Colts 33, Miami Dolphins 8, box score, stats
- Week 2: Colts 29, Denver Broncos 28, box score, stats
- Week 3: Colts 41, Tennessee Titans 20, box score, stats
- Week 4: Los Angeles Rams 27, Colts 20 box score, stats
- Week 5: Sunday, Oct. 5, vs. Las Vegas Raiders, 1 p.m., Fox
- Week 6: Sunday, Oct. 12, vs. Arizona Cardinals, 1 p.m., Fox
- Week 7: Sunday, Oct. 19, at Los Angeles Chargers, 4:05 p.m., CBS
- Week 8: Sunday, Oct. 26, vs. Tennessee Titans, 4:25 p.m., CBS
- Week 9: Sunday, Nov. 2, at Pittsburgh Steelers, 1 p.m., CBS
- Week 10: Sunday, Nov. 9, vs. Atlanta Falcons in Berlin, Germany, 9:30 a.m., NFL Network
- Week 11: Bye
- Week 12: Sunday, Nov. 23, at Kansas City Chiefs, 1 p.m., CBS
- Week 13: Sunday, Nov. 30, vs. Houston Texans, 1 p.m., CBS
- Week 14: Sunday, Dec. 7, at Jacksonville Jaguars, 1 p.m., CBS
- Week 15: Sunday, Dec. 14, at Seattle Seahawks, 4:25 p.m., CBS
- Week 16: Monday, Dec. 22, vs. San Francisco 49ers, 8:15 p.m., ESPN‘s “Monday Night Football”
- Week 17: Sunday, Dec. 28, vs. Jacksonville Jaguars, 1 p.m., Fox
- Week 18: Date TBD, at Houston Texans, time TBD, TBD
Joel A. Erickson covers the Colts all season. Get more coverage on IndyStarTV and with the Colts Insider newsletter.
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