The injury report for the San Francisco 49ers (3-1) heading into their matchup against the Los Angeles Rams (3-1) has 12 players. The contest starts at 8:15 p.m. ET on Thursday, Oct. 2, at SoFi Stadium.
Watch Los Angeles Rams vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)
49ers vs Rams TV channel & game info
- Game day: Thursday, October 2, 2025
- Game time: 8:15 p.m. ET
- Location: Inglewood, California
- Stadium: SoFi Stadium
- TV channel: Amazon Prime Video
- Live stream: Watch on Fubo! (Regional restrictions may apply)
- Live stream: Watch on Amazon Prime!
Watch Los Angeles Rams vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)
49ers injury report
Jordan Watkins | WR (Out)
- Injury: Calf
- Practice Status: Did Not Participate In Practice
Brock Purdy | QB (Out)
- Injury: Toe
- Practice Status: Did Not Participate In Practice
- 2025 Passing: 73-for-48 | 586 Yards | 4 Touchdowns | 4 Interceptions
Ricky Pearsall | WR (Out)
- Injury: Knee
- Practice Status: Did Not Participate In Practice
- 2025 Receiving Stats: 29 Targets | 20 Receptions | 327 Yards | 0 Touchdowns
Jauan Jennings | WR (Out)
- Injury: Ankle
- Practice Status: Did Not Participate In Practice
- 2025 Receiving Stats: 19 Targets | 9 Receptions | 129 Yards | 1 Touchdown
Robert Beal | DL (Out)
- Injury: Ankle
- Practice Status: Did Not Participate In Practice
- 2024 Defensive Performance: 0.0 Sacks | 0.0 Tackles for Loss | 11 Tackles | 0 Interceptions | 0 Passes Defended
CJ West | DT (Questionable)
- Injury: Thumb
- Practice Status: Limited Participation in Practice
- 2025 Defensive Stats: 0.0 Sacks | 0.0 Tackles for Loss | 2 Tackles | 0 Interceptions | 0 Passes Defended
Dee Winters | LB
- Injury: Knee
- Practice Status: Full Participation in Practice
- 2025 Defensive Stats: 0.0 Sacks | 3.0 Tackles for Loss | 32 Tackles | 0 Interceptions | 2 Passes Defended
Mykel Williams | DL
- Injury: Wrist
- Practice Status: Full Participation in Practice
- 2025 Defensive Stats: 0.0 Sacks | 3.0 Tackles for Loss | 10 Tackles | 0 Interceptions | 0 Passes Defended
Colton McKivitz | OL
- Injury: Calf
- Practice Status: Full Participation in Practice
- 2025 Season Stats: 1 Games Played
Mac Jones | QB
- Injury: Knee
- Practice Status: Full Participation in Practice
- 2025 Passing: 80-for-53 | 563 Yards | 4 Touchdowns | 1 Interception
Yetur Gross-Matos | DL
- Injury: Knee
- Practice Status: Full Participation in Practice
Renardo Green | CB
- Injury: Neck
- Practice Status: Full Participation in Practice
- 2025 Defensive Stats: 0.0 Sacks | 0.0 Tackles for Loss | 13 Tackles | 0 Interceptions | 3 Passes Defended
49ers insights
- The 49ers have been a top-five unit on both sides of the ball this season, as they rank fifth-best in total yards per game (368.0) and fifth-best in total yards surrendered per game (280.5).
- When San Francisco records more than 20.3 points, it is 1-1 against the spread and 1-1 overall.
- The 49ers’ passing attack has been paving the way for the team, as they rank second-best in the NFL with 280.0 passing yards per game. In terms of defense, they are surrendering 165.0 passing yards per game, which ranks sixth.
- San Francisco averages 83.5 more yards per game (368.0) than Los Angeles gives up (284.5).
49ers vs Rams odds
NFL odds courtesy of BetMGM. Odds updated Thursday at 1:29 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
- Spread Favorite: Rams (-8.5)
- Moneyline: Rams (-450), 49ers (+349)
- Total: 45.5 points
Watch Los Angeles Rams vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)
Our team of savvy editors independently handpicks all recommendations. If you purchase through our links, the USA Today Network may earn a commission. Prices were accurate at the time of publication but may change.
Gambling involves risk. Please only gamble with funds that you can comfortably afford to lose. While we do our utmost to offer good advice and information we cannot be held responsible for any loss that may be incurred as a result of gambling. We do our best to make sure all the information that we provide on this site is correct. However, from time to time mistakes will be made and we will not be held liable. Please check any stats or information if you are unsure how accurate they are. No guarantees are made with regards to results or financial gain. All forms of betting carry financial risk and it is up to the individual to make bets with or without the assistance of information provided on this site and we cannot be held responsible for any loss that may be incurred as a result of following the betting tips provided on this site. Past performances do not guarantee success in the future and betting odds fluctuate from one minute to the next. The material contained on this site is intended to inform, entertain and educate the reader and in no way represents an inducement to gamble legally or illegally or any sort of professional advice.
Gannett may earn revenue from sports betting operators for audience referrals to betting services. Sports betting operators have no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. Terms apply, see operator site for Terms and Conditions. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24/7 at 1-800-GAMBLER (NJ, OH), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA), 1-800-9-WITH-IT (IN). Must be 21 or older to gamble. Sports betting and gambling are not legal in all locations. Be sure to comply with laws applicable where you reside. It is your sole responsibility to act in accordance with your local laws.
